Commit d1a89d61 authored by Carlos GO's avatar Carlos GO
Browse files

maternal units

parent 4ecd5c06
......@@ -137,7 +137,7 @@ The reviewer is correct. It is has been fixed in the manuscript.
\begin{response}{
Section 4.1.2 - R has units of kcal mol-1 K-1 (which are not stated). Then RT = 0.06 kcal/mol. Although it seems reasonable to use this RT in the selection function, there is of course no reason why fitness has to depend on the Boltzmann factor. Use of beta in this equation is potentially confusing because often beta = 1/kT, and you have a 1/RT already. Maybe call beta something else, or just miss beta out of the equation. Later in this paragraph - shouldn't it be beta = +1 not -1, because more negative E means higher fitness? There is already a minus sign in the equation.}
The use of RT in the fitness function was to scale fitness in a way that could be readily compared with \texttt{RNAmutants}. The use of $\beta=-1$ is necessary as energy values are either zero or negative. If $\beta = +1$ then the exponent would remain negative and a more negative energy would then result in a lower fitness structure.
The units of R are stated in the paragraph following the fitness function. The use of RT in the fitness function was to scale fitness in a way that could be readily compared with \texttt{RNAmutants}. The use of $\beta=-1$ is necessary as energy values are either zero or negative. If $\beta = +1$ then the exponent would remain negative and a more negative energy would then result in a lower fitness structure.
\end{response}
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