Our software, \soft, is implemented in \texttt{python 2.7}. To identify mutations of interest, the threshold of \shape profile disruption was tested between the $95$ and $99$ percentiles. The parameter $\delta$ was set to $10$ creating windows of size $21$ to measure the local \shape profile disruptions. The parameter $\gamma$ was evaluated for values between $0$ and $30$. The whole implementation is freely available at:
Our software, \soft, is implemented in \texttt{python 2.7}. To identify mutations of interest, the threshold of \shape profile disruption was tested between the $95$ and $99$ percentiles. The parameter {\color{red}$\lambda$} was set to $10$ creating windows of size $21$ to measure the local \shape profile disruptions. The parameter $\gamma$ was evaluated for values between $0$ and $30$. The whole implementation is freely available at: